Treatment Type: Medications
Rated for: German Shepherd Dog
Posted Jun. 1, 2018
Prednisolone is pretty much every vets go-to systemic corticosteroid, whenever such a treatment is necessary. It's the same in the case of Addison's disease, however, prednisolone only has glucocorticoid activity, and in order to maintain homeostasis both glucocorticoid and mineralocorticoids are necessary. This is why prednisolone is combinedc with DOCP (Desoxycorticosterone) which act as a mineralocorticoid.
In this type of treatment prednisolone is given orally every 12 or 24 hours, while DOCP is given by injection every 25 days or so, depending on the response to the treatment.
Alternative to this treatment is single agent fludrocortisone therapy, which can be good, but has it's downsides, and it might require addition of prednisolone at times of stress. Research has shown that combination of prednisolone and DOCP provides better hormonal and metabolic stability.