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Treatment Name: Diagnostic Tests: Alanine Transaminase (ALT) Test

Treatment Type: Diagnostic Procedures

Rated for: Collie (Smooth)

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An increase in ALT most commonly signifies a condition or disease affecting the liver.

M Boyd BVSc MRCVS

By

5.0

United Kingdom

Posted Mar. 27, 2018

ALT is a enzyme which is mainly released when liver cells are damaged.

It is usually interpreted along with other blood results which commonly increase in liver disease: ALP, GGT, total bilirubin, bile acids etc.

Further tests such as blood tests and imaging (x-rays, ultrasound, CT) as well as liver samples (FNA or biopsy) may need to be taken to come to a complete diagnosis.

ALT levels in the blood most commonly increase due to:
1. Infections in the liver
2. Chronic liver disease
3. Pancreatitis
4. Medications: phenobarbital (seizure medication), steroids, NSAIDs
5. Reduced blood flow to the liver: heart disease, anaemia
6. Cushing's Disease or Diabetes Mellitus
7. Liver Cancer
8. Toxins: poisonous mushrooms, xylitol etc

The levels of ALT can also increase mildly due to muscle injury or gastrointestinal disease.

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