Treatment Type: Medications
Rated for: American Staffordshire Terrier / Bulldog Mix
Bryan, Texas, United States
Posted Dec. 11, 2018
Allergic dermatitis can cause severe itchiness (pruritis) in pets and can be a nuisance for owners. Pruritis can occur for many reasons, however, and it is important to rule out other options before concluding the diagnosis of allergies. The categories of rule outs are skin infections (bacterial, yeast, and dermatophytes), parasites (fleas, mites, lice), and then allergies ( flea allergy dermatitis, food allergy, and canine atopic dermatitis).
The pruritic effect of atopic dermatitis is primarily mediated by molecules called cytokines, with the principle cytokine being interleukin- 31 (IL-31). IL-31 binds to receptors on cells which then causes an intracellular cascade of events, leading to pruritis. Cytopoint (lokivetmab) is an antibody that works by binding to IL-31 before it even reaches the receptors on the cells. Cytopoint is very effective and safe for dogs. It is convenient, especially for owners who do not want to “pill” their dog every day as it is an injection that can last for several weeks at a time. It can also be used for dogs under the age of 12 months, unlike a similar medication, Apoquel. It is also a great option for owners that are looking for a “non-drug” option.