Activyl (indoxacarb) is a monthly, topical (spot-on) solution for killing fleas in dogs and cats. Activyl (indoxacarb) is approved for the control and treatment of flea including eggs and larvae as well as adult flea in dogs, puppies, cats and kittens.
Time after administration to kill fleas: 93% by 12 hours after first application; 100% by 12 hours after re-infestation on Day 7, 14, and 21; 100% by 24 hours on Day 28.
Approved for: dogs greater than 8 weeks and 4 lbs. Cats greater than 8 weeks and 2 lbs.
Also controls: Activyl Tick Plus for dogs only.
Comments: Indoxacarb itself is not effective, but it is converted into the active molecule in the gut of susceptible insects (bioactivation), whereas mammals break it down into inactive metabolites. This, together with other differences between indoxacarb’s effect on mammals and insects, gives it an excellent safety profile. Like many of the chemicals now used in flea control products, indoxacarb was first developed to control food crop pests. Activyl Tick Plus for dogs also contains permethrin and is only to be used on dogs.
By Jon Plant, DVM, DACVD