Clozaril etc. (clozapine) is the first “atypical antipsychotic” medication. For dogs, clozapine is very rarely used to treat extreme agression and injurious behavior.
In humans, atypical antipsychotics are used to treat psychotic conditions (severe mental disorders characterized by distorted thoughts, perceptions, and emotions) such as schizophrenia. Like the other atypical antipsychotics, clozaril appears to work by blocking the action of the neurotransmitters serotonin and dopamine, thus producing a tranquilizing and antipsychotic effect.